PROPERTIES : Pharmacodynamic properties : Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group, which acts by inhibition of DNA gyrase. It has a broad-spectrum activity in vitro against a wide range of bacteria, particularly Gram-negative bacteria but also against Gram-positive bacteria. Pharmacokinetic particulars After a single intramuscular administration in cattle at the recommended dose of 8 mg/kg, the maximum plasma concentration of marbofloxacin (Cmax) is 8 µg/ml. Binding to plamsa proteins is about 30%. Marbofloxacin is eliminated slowly, predominantly in the active form in urine and faeces. After subcutaneous administration at the recommended dose of 2 mg/kg, marbofloxacin is readily absorbed and reaches maximal plasma concentrations of 1.7 µg/ml. Its bioavailability is close to 100%. Marbofloxacin is weakly bound to plasma proteins (30%), extensively distributed and in most tissues (liver, kidney, skin, lung, bladder, uterus) it achieves higher concentrations than in plasma. Marbofloxacin is eliminated predominantly in the active form in urine and faeces.
20 dirhams
200 dirhams
PROPERTIES : Pharmacodynamic properties : Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group, which acts by inhibition of DNA gyrase. It has a broad-spectrum activity in vitro against a wide range of bacteria, particularly Gram-negative bacteria but also against Gram-positive bacteria. Pharmacokinetic particulars After a single intramuscular administration in cattle at the recommended dose of 8 mg/kg, the maximum plasma concentration of marbofloxacin (Cmax) is 8 µg/ml. Binding to plamsa proteins is about 30%. Marbofloxacin is eliminated slowly, predominantly in the active form in urine and faeces. After subcutaneous administration at the recommended dose of 2 mg/kg, marbofloxacin is readily absorbed and reaches maximal plasma concentrations of 1.7 µg/ml. Its bioavailability is close to 100%. Marbofloxacin is weakly bound to plasma proteins (30%), extensively distributed and in most tissues (liver, kidney, skin, lung, bladder, uterus) it achieves higher concentrations than in plasma. Marbofloxacin is eliminated predominantly in the active form in urine and faeces.
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